8-K

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported)

January 14, 2020

 

 

Oyster Point Pharma, Inc.

(Exact name of registrant as specified in its charter)

 

 

 

Delaware   001-39112   81-1030955

(State or other jurisdiction

of incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

202 Carnegie Center, Suite 109

Princeton, New Jersey 08540

(Address, including zip code, of Registrant’s principal executive offices)

(609) 382-9032

(Registrant’s telephone number, including area code)

Not Applicable

(Former name or former address, if changed since last report)

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class

 

Trading

Symbol(s)

 

Name of each exchange

on which registered

Common Stock, par value $0.001 per share   OYST   The Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company  ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☒

 

 

 


Item 7.01.

Regulation FD Disclosure.

January 2020 Corporate Presentation

On January 14, 2020, Oyster Point Pharma, Inc. (the “Company”) posted a corporate presentation dated January 2020 providing a general corporate update on the business to the “Events & Presentations” page within the “Investors” section of the Company’s website at https://investors.oysterpointrx.com. The Company intends to use this presentation at the 38th Annual J.P. Morgan Healthcare Conference in San Francisco, California beginning on January 14, 2020 as well as in future meetings with analysts, investors and others from time to time. An excerpt of the corporate presentation is attached hereto as Exhibit 99.1 and is incorporated by reference herein.

The information in this Item 7.01 of this Form 8-K and the attached Exhibit 99.1 are being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, except as expressly set forth by specific reference in such a filing.

The information contained in the presentation is summary information that is intended to be considered in the context of more complete information included in the Company’s filings with the SEC and other public announcements that the Company has made and may make from time to time by press release or otherwise. The Company does not undertake any duty or obligation to update or revise the information contained in this report, although the Company may do so from time to time as the management team believes is appropriate. Any such updating may be made through the filing of other reports or documents with the SEC, through press releases or through other public disclosures. For important information about forward looking statements, see the slide titled “Disclaimers and Forward Looking Statements” in Exhibit 99.1 attached hereto.

 

Item 9.01.

Financial Statements and Exhibits.

 

(d)

Exhibits.

 

Exhibit

    No.    

  

Description

99.1    January 2020 Corporate Presentation.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

OYSTER POINT PHARMA, INC.

By:

 

/s/ Jeffrey Nau

 

Jeffrey Nau, Ph.D., M.M.S.

 

President and Chief Executive Officer

Date: January 14, 2020

EX-99.1

Exhibit 99.1 January 2020 Corporate Update NASDAQ: OYSTExhibit 99.1 January 2020 Corporate Update NASDAQ: OYST


Disclaimers and Forward Looking Statements This presentation contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 that reflect the current beliefs, expectations and assumptions of Oyster Point Pharma, Inc. (the “Company,” “we” or “our”) regarding the future of its business, its future plans and strategies, clinical results, future financial condition and other future conditions. All statements other than statements of historical facts contained in this presentation, including statements regarding future results of operations and financial position, business strategy, product candidates, planned preclinical studies and clinical trials, results of clinical trials, research and development costs, regulatory approvals, timing and likelihood of success, as well as plans and objectives of management for future operations, are forward-looking statements. The words “may,” “will,” “should,” “would,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, among other things: market conditions, the likelihood of our clinical trials demonstrating safety and efficacy of our product candidates, and other positive results; the timing of initiation of our future clinical trials, and the reporting of data from our current and future trials; our plans relating to the clinical development of our product candidates, including the size, number and disease areas to be evaluated; the size of the market opportunity and prevalence of dry eye disease (DED) for our product candidates; our plans relating to commercializing our product candidates, if approved, including the geographic areas of focus and sales strategy; the success of competing therapies that are or may become available; our estimates of the number of patients in the United States who suffer from DED and the number of patients that will enroll in our clinical trials; the beneficial characteristics, safety, efficacy and therapeutic effects of our product candidates; the timing or likelihood of regulatory filings and approval for our product candidates; our ability to obtain and maintain regulatory approval of our product candidates; our plans relating to the further development and manufacturing of our product candidates, including additional indications for which we may pursue; the expected potential benefits of strategic collaborations with third parties and our ability to attract collaborators with development, regulatory and commercialization expertise; existing regulations and regulatory developments in the United States and other jurisdictions; our plans and ability to obtain or protect intellectual property rights, including extensions of existing patent terms where available; our continued reliance on third parties to conduct additional clinical trials of our product candidates, and for the manufacture of our product candidates for preclinical studies and clinical trials; the accuracy of our estimates regarding expenses, future revenue, capital requirements and needs for additional financing; our financial performance; the sufficiency of our existing capital resources to fund our future operating expenses and capital expenditure requirements; our expectations regarding the period during which we will qualify as an emerging growth company under the JOBS Act; our anticipated use of our existing resources and the proceeds from our initial public offering; and other risks described in the “Risk Factors” section included in our public filings that we have made and will make with the Securities and Exchange Commission (SEC). The forward-looking statements in this presentation represent our views as of the date of this presentation. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. No representations or warranties (expressed or implied) are made about the accuracy of any such forward- looking statements. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. We have filed and will file Current Reports on Form 8-K, Quarterly Reports on Form 10-Q and Annual Reports on Form 10-K, and other documents with the SEC. You should read these documents for more complete information about us. You may obtain these documents for free by visiting EDGAR on the SEC website at www.sec.gov. This presentation concerns products that are under clinical investigation and which have not yet been approved for marketing by the U.S. Food and Drug Administration. They are currently limited by Federal law to investigational use, and no representation is made as to their safety or effectiveness for the purposes for which they are being investigated. 2 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryDisclaimers and Forward Looking Statements This presentation contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 that reflect the current beliefs, expectations and assumptions of Oyster Point Pharma, Inc. (the “Company,” “we” or “our”) regarding the future of its business, its future plans and strategies, clinical results, future financial condition and other future conditions. All statements other than statements of historical facts contained in this presentation, including statements regarding future results of operations and financial position, business strategy, product candidates, planned preclinical studies and clinical trials, results of clinical trials, research and development costs, regulatory approvals, timing and likelihood of success, as well as plans and objectives of management for future operations, are forward-looking statements. The words “may,” “will,” “should,” “would,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, among other things: market conditions, the likelihood of our clinical trials demonstrating safety and efficacy of our product candidates, and other positive results; the timing of initiation of our future clinical trials, and the reporting of data from our current and future trials; our plans relating to the clinical development of our product candidates, including the size, number and disease areas to be evaluated; the size of the market opportunity and prevalence of dry eye disease (DED) for our product candidates; our plans relating to commercializing our product candidates, if approved, including the geographic areas of focus and sales strategy; the success of competing therapies that are or may become available; our estimates of the number of patients in the United States who suffer from DED and the number of patients that will enroll in our clinical trials; the beneficial characteristics, safety, efficacy and therapeutic effects of our product candidates; the timing or likelihood of regulatory filings and approval for our product candidates; our ability to obtain and maintain regulatory approval of our product candidates; our plans relating to the further development and manufacturing of our product candidates, including additional indications for which we may pursue; the expected potential benefits of strategic collaborations with third parties and our ability to attract collaborators with development, regulatory and commercialization expertise; existing regulations and regulatory developments in the United States and other jurisdictions; our plans and ability to obtain or protect intellectual property rights, including extensions of existing patent terms where available; our continued reliance on third parties to conduct additional clinical trials of our product candidates, and for the manufacture of our product candidates for preclinical studies and clinical trials; the accuracy of our estimates regarding expenses, future revenue, capital requirements and needs for additional financing; our financial performance; the sufficiency of our existing capital resources to fund our future operating expenses and capital expenditure requirements; our expectations regarding the period during which we will qualify as an emerging growth company under the JOBS Act; our anticipated use of our existing resources and the proceeds from our initial public offering; and other risks described in the “Risk Factors” section included in our public filings that we have made and will make with the Securities and Exchange Commission (SEC). The forward-looking statements in this presentation represent our views as of the date of this presentation. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. No representations or warranties (expressed or implied) are made about the accuracy of any such forward- looking statements. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. We have filed and will file Current Reports on Form 8-K, Quarterly Reports on Form 10-Q and Annual Reports on Form 10-K, and other documents with the SEC. You should read these documents for more complete information about us. You may obtain these documents for free by visiting EDGAR on the SEC website at www.sec.gov. This presentation concerns products that are under clinical investigation and which have not yet been approved for marketing by the U.S. Food and Drug Administration. They are currently limited by Federal law to investigational use, and no representation is made as to their safety or effectiveness for the purposes for which they are being investigated. 2 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Redefining Dry Eye Treatment with a Nasal Spray Redefining Dry Eye Treatment with a Nasal Spray


Where Others See Challenges, We See Potential Dry Eye Disease Remains Significant Area of Unmet Need Limitations of current treatments: • Mechanisms of action only address inflammation • Slow onset of action • Tolerability and compliance issues Despite these limitations, currently available drugs are blockbusters 4 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryWhere Others See Challenges, We See Potential Dry Eye Disease Remains Significant Area of Unmet Need Limitations of current treatments: • Mechanisms of action only address inflammation • Slow onset of action • Tolerability and compliance issues Despite these limitations, currently available drugs are blockbusters 4 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


There is No Substitute for Natural Tear Film A healthy tear film lubricates and protects the eyes from injury and infection, washes away foreign particles, and contributes refractive power for clear vision Growth factors, such as nerve growth factor (NGF) and epidermal growth factor (EGF), found in natural human tears are critical regulators for corneal wound healing Natural tears contain a complex mixture of lipids, proteins, mucins, and electrolytes • Over 1,500 proteins • Contains growth factors and has anti-inflammatory • 5+ lipid classes and antimicrobial • 20+ mucins properties Klenkler, B., Sheardown, H., & Jones, L. (2007). Growth factors in the tear film: role in tissue maintenance, wound healing, and ocular pathology. The ocular surface, 5(3), 228-239. Willcox, M. D., Argüeso, P., Georgiev, G. A., Holopainen, J. M., Laurie, G. W., Millar, T. J., ... & Suarez, T. (2017). TFOS DEWS II tear film report. The ocular surface, 15(3), 366-403. 5 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryThere is No Substitute for Natural Tear Film A healthy tear film lubricates and protects the eyes from injury and infection, washes away foreign particles, and contributes refractive power for clear vision Growth factors, such as nerve growth factor (NGF) and epidermal growth factor (EGF), found in natural human tears are critical regulators for corneal wound healing Natural tears contain a complex mixture of lipids, proteins, mucins, and electrolytes • Over 1,500 proteins • Contains growth factors and has anti-inflammatory • 5+ lipid classes and antimicrobial • 20+ mucins properties Klenkler, B., Sheardown, H., & Jones, L. (2007). Growth factors in the tear film: role in tissue maintenance, wound healing, and ocular pathology. The ocular surface, 5(3), 228-239. Willcox, M. D., Argüeso, P., Georgiev, G. A., Holopainen, J. M., Laurie, G. W., Millar, T. J., ... & Suarez, T. (2017). TFOS DEWS II tear film report. The ocular surface, 15(3), 366-403. 5 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Loss of Tear Film Leads to Progression of Dry Eye Disease Cycle of Dry Eye Disease Healthy Ocular Surface Loss of Tear Film Homeostasis Leads to Inflammation Tear Film Homeostasis Fundamental Characteristic of DED and Cell Damage Tear Deficiency & Instability Increased Evaporation Inflammation Irritation & Cell Damage Decreased Tear Volume RESTASIS®, XIIDRA® & other DED pipeline Epithelial Mucin Aqueous Lipid Product candidates primarily address DED Cells further down disease continuum 6 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryLoss of Tear Film Leads to Progression of Dry Eye Disease Cycle of Dry Eye Disease Healthy Ocular Surface Loss of Tear Film Homeostasis Leads to Inflammation Tear Film Homeostasis Fundamental Characteristic of DED and Cell Damage Tear Deficiency & Instability Increased Evaporation Inflammation Irritation & Cell Damage Decreased Tear Volume RESTASIS®, XIIDRA® & other DED pipeline Epithelial Mucin Aqueous Lipid Product candidates primarily address DED Cells further down disease continuum 6 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Breaks this Cycle to Re-Establish Natural Tear Film Production through its Novel MOA Cycle of Dry Eye Disease Healthy Ocular Surface Loss of Tear Film Homeostasis Leads to Inflammation Tear Film Homeostasis Fundamental Characteristic of DED and Cell Damage Tear Deficiency & Instability Increased Evaporation Inflammation Irritation & Cell Damage Decreased Tear Volume OC-01 is designed to address Epithelial Mucin Aqueous Lipid the fundamental characteristic Cells of DED by reestablishing natural tear film production to improve the signs and symptoms of DED 7 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Breaks this Cycle to Re-Establish Natural Tear Film Production through its Novel MOA Cycle of Dry Eye Disease Healthy Ocular Surface Loss of Tear Film Homeostasis Leads to Inflammation Tear Film Homeostasis Fundamental Characteristic of DED and Cell Damage Tear Deficiency & Instability Increased Evaporation Inflammation Irritation & Cell Damage Decreased Tear Volume OC-01 is designed to address Epithelial Mucin Aqueous Lipid the fundamental characteristic Cells of DED by reestablishing natural tear film production to improve the signs and symptoms of DED 7 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Nasal Delivery is Critical to the Novel MOA Parasympathetic Nervous System controls tear film homeostasis The trigeminal nerve provides the pathway for parasympathetic stimulation of the Lacrimal Functional Unit (LFU) to promote complete natural tear film The trigeminal nerve is accessible within the nasal cavity and can be activated by stimulating nicotinic acetylcholine receptors (nAChR) 1 34% of basal tear production is due to inhaling air through the nose 1 Gupta, A., Heigle, T., & Pflugfelder, S. C. (1997). Nasolacrimal stimulation of aqueous tear production. Cornea, 16(6), 645-648. 8 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryNasal Delivery is Critical to the Novel MOA Parasympathetic Nervous System controls tear film homeostasis The trigeminal nerve provides the pathway for parasympathetic stimulation of the Lacrimal Functional Unit (LFU) to promote complete natural tear film The trigeminal nerve is accessible within the nasal cavity and can be activated by stimulating nicotinic acetylcholine receptors (nAChR) 1 34% of basal tear production is due to inhaling air through the nose 1 Gupta, A., Heigle, T., & Pflugfelder, S. C. (1997). Nasolacrimal stimulation of aqueous tear production. Cornea, 16(6), 645-648. 8 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Tear Film is Produced by the Lacrimal Functional Unit LACRIMAL GLANDS Produce the aqueous which contains proteins, enzymes, antibodies and growth factors that are cytoprotective, anti-inflammatory, and anti-microbial. MEIBOMIAN GLANDS Produce the lipid layer which reduces evaporation and promotes tear film stability. GOBLET CELLS Produce mucins which bind water from the mucins aqueous layer and allow for spreading of the aqueous lipid layer aqueous layer over the ocular surface and help stabilize the tear film. 9 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryTear Film is Produced by the Lacrimal Functional Unit LACRIMAL GLANDS Produce the aqueous which contains proteins, enzymes, antibodies and growth factors that are cytoprotective, anti-inflammatory, and anti-microbial. MEIBOMIAN GLANDS Produce the lipid layer which reduces evaporation and promotes tear film stability. GOBLET CELLS Produce mucins which bind water from the mucins aqueous layer and allow for spreading of the aqueous lipid layer aqueous layer over the ocular surface and help stabilize the tear film. 9 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 is a Selective Nicotinic Agonist • Preservative-free nasal spray containing the selective nicotinic acetylcholine receptor agonist, varenicline. • Binds to receptors located on the trigeminal nerve readily accessible within anterior portion of the nasal cavity to open ion channels and depolarize the nerve. • Nerve is activated, and lacrimal functional unit is stimulated to produce natural tears. 10 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 is a Selective Nicotinic Agonist • Preservative-free nasal spray containing the selective nicotinic acetylcholine receptor agonist, varenicline. • Binds to receptors located on the trigeminal nerve readily accessible within anterior portion of the nasal cavity to open ion channels and depolarize the nerve. • Nerve is activated, and lacrimal functional unit is stimulated to produce natural tears. 10 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Mechanism of Action of OC-01 11 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryMechanism of Action of OC-01 11 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Attributes Deliver Against Unmet Needs in Dry Eye Affects 34 MILLION ADULTS Novel mechanism of action to restore tear 1 of all ages in the U.S. alone homeostasis with natural tear production 2 and >340 million worldwide Rapid onset of action demonstrated in clinical ~16 MILLION trials to significantly improve signs and symptoms have been diagnosed, but < 2 million are Improvement in tear production demonstrated currently treated in the majority of patients ~7 MILLION PEOPLE Favorable tolerability - no burning/stinging, taste or smell have tried current options 1. Paulsen AJ, Cruickshanks KJ, Fischer ME, Huang GH, Klein BE, Klein R, Dalton DS. Dry eye in the beaver dam offspring study: prevalence, risk factors, and health-related quality of life. American Journal of Ophthalmology. 2014 Apr;157(4):799-806. 2. Market Scope 2016 Dry Eye Products Report: A Global Market Analysis for 2015 to 2021 12 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Attributes Deliver Against Unmet Needs in Dry Eye Affects 34 MILLION ADULTS Novel mechanism of action to restore tear 1 of all ages in the U.S. alone homeostasis with natural tear production 2 and >340 million worldwide Rapid onset of action demonstrated in clinical ~16 MILLION trials to significantly improve signs and symptoms have been diagnosed, but < 2 million are Improvement in tear production demonstrated currently treated in the majority of patients ~7 MILLION PEOPLE Favorable tolerability - no burning/stinging, taste or smell have tried current options 1. Paulsen AJ, Cruickshanks KJ, Fischer ME, Huang GH, Klein BE, Klein R, Dalton DS. Dry eye in the beaver dam offspring study: prevalence, risk factors, and health-related quality of life. American Journal of Ophthalmology. 2014 Apr;157(4):799-806. 2. Market Scope 2016 Dry Eye Products Report: A Global Market Analysis for 2015 to 2021 12 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Nasal Spray Clinical Development Program Top-line safety & efficacy data from 84-Day dosing in the MYSTIC Trial Neurotrophic Dry Eye Disease Keratitis PHASE 1 PHASE 2b PHASE 2 PHASE 3 PHASE 2 28-Day Long-term 84 Day 28-Day 56-Day PK Study Safety & Efficacy Safety & Efficacy Efficacy & Safety Safety & Efficacy Expected Complete Complete Complete Expected Mid-2020 Start 2H 2020 *Planning OC-01 label expansion for contact lens intolerance and ocular surface preparation for refractive surgeries 13 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Nasal Spray Clinical Development Program Top-line safety & efficacy data from 84-Day dosing in the MYSTIC Trial Neurotrophic Dry Eye Disease Keratitis PHASE 1 PHASE 2b PHASE 2 PHASE 3 PHASE 2 28-Day Long-term 84 Day 28-Day 56-Day PK Study Safety & Efficacy Safety & Efficacy Efficacy & Safety Safety & Efficacy Expected Complete Complete Complete Expected Mid-2020 Start 2H 2020 *Planning OC-01 label expansion for contact lens intolerance and ocular surface preparation for refractive surgeries 13 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Phase 1 Study Design Open-Label, Single-Center, Randomized, 2-way Crossover Study to Evaluate the Relative Bioavailability of Varenicline Administered as OC-01 Nasal Spray Compared to Varenicline Administered Orally 1.2 mg/ml n=11 Varenicline OC-01 Oral Tablet Nasal Spray Randomized 14 Day 1:1 Wash-Out 1.2 mg/ml n=11 Varenicline OC-01 Oral Tablet Nasal Spray 14 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Phase 1 Study Design Open-Label, Single-Center, Randomized, 2-way Crossover Study to Evaluate the Relative Bioavailability of Varenicline Administered as OC-01 Nasal Spray Compared to Varenicline Administered Orally 1.2 mg/ml n=11 Varenicline OC-01 Oral Tablet Nasal Spray Randomized 14 Day 1:1 Wash-Out 1.2 mg/ml n=11 Varenicline OC-01 Oral Tablet Nasal Spray 14 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Nasal Spray Provides Low Systemic Exposure Systemic Exposure Mean Plasma Concentration vs. Time Highlights: • Relative bioavailability* is 13 times lower for OC-01 nasal spray as compared to oral varenicline Oral Varenicline • Maximal concentration** was 14 times Nasal Varenicline lower for OC-01 nasal spray as compared to oral varenicline *Systemic exposure as defined by adjusted geometric mean AUC ; 7.46 vs 99.67 h*ng/ml 0-inf Representative volunteer profile **Maximal concentration as defined by adjusted geometric mean C ; (0.32 vs 4.55 ng/ml) max 15 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryNasal Spray Provides Low Systemic Exposure Systemic Exposure Mean Plasma Concentration vs. Time Highlights: • Relative bioavailability* is 13 times lower for OC-01 nasal spray as compared to oral varenicline Oral Varenicline • Maximal concentration** was 14 times Nasal Varenicline lower for OC-01 nasal spray as compared to oral varenicline *Systemic exposure as defined by adjusted geometric mean AUC ; 7.46 vs 99.67 h*ng/ml 0-inf Representative volunteer profile **Maximal concentration as defined by adjusted geometric mean C ; (0.32 vs 4.55 ng/ml) max 15 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Phase 2b Study Design Multicenter, Randomized, Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease Placebo n=43 (Vehicle Control) Primary (sign) Endpoint: Schirmer’s Score 0.12 mg/ml n=47 Randomized at Week 4 OC-01 Schirmer’s 1:1:1:1 Nasal Spray Score ≤10 mm Primary (symptom) Endpoint: OSDI ≥23 0.6 mg/ml BID n=48 Visual analog eye dryness score n=182 OC-01 28 Days (EDS) at Weeks 3 & 4 Subjects Nasal Spray 1.2 mg/ml n=44 OC-01 Nasal Spray 16 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Phase 2b Study Design Multicenter, Randomized, Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease Placebo n=43 (Vehicle Control) Primary (sign) Endpoint: Schirmer’s Score 0.12 mg/ml n=47 Randomized at Week 4 OC-01 Schirmer’s 1:1:1:1 Nasal Spray Score ≤10 mm Primary (symptom) Endpoint: OSDI ≥23 0.6 mg/ml BID n=48 Visual analog eye dryness score n=182 OC-01 28 Days (EDS) at Weeks 3 & 4 Subjects Nasal Spray 1.2 mg/ml n=44 OC-01 Nasal Spray 16 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Statistically Significant Improvement in Signs Mean Change from Baseline % Subjects with ≥10mm Change in Schirmer’s Score Day 28 vs. Baseline Schirmer’s Score (mm) Day 28 Primary Endpoint P<0.001 P<0.001 P=0.001 P<0.001 P=0.001 11.4 11.1 54% 10.1 48% 45% 3.7 14% n=43 n=47 n=46 n=40 n=43 n=47 n=46 n=40 *ITT-observed population * ITT-observed population Pearson chi-squared p-value ANCOVA, Least Squares mean Placebo 0.12 mg/ml 0.6 mg/ml 1.2 mg/ml 17 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score (mm) % Subjects with ≥10mm Change in Schirmer’s ScoreStatistically Significant Improvement in Signs Mean Change from Baseline % Subjects with ≥10mm Change in Schirmer’s Score Day 28 vs. Baseline Schirmer’s Score (mm) Day 28 Primary Endpoint P<0.001 P<0.001 P=0.001 P<0.001 P=0.001 11.4 11.1 54% 10.1 48% 45% 3.7 14% n=43 n=47 n=46 n=40 n=43 n=47 n=46 n=40 *ITT-observed population * ITT-observed population Pearson chi-squared p-value ANCOVA, Least Squares mean Placebo 0.12 mg/ml 0.6 mg/ml 1.2 mg/ml 17 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score (mm) % Subjects with ≥10mm Change in Schirmer’s Score


Statistically Significant Improvement in Symptoms Mean Change from Baseline in Eye Mean Change from Baseline in Eye 1 2 Dryness Score (EDS) – Day 21 Dryness Score (EDS) – Day 28 Controlled Adverse Environment (CAE) Secondary Symptom Endpoint Secondary Symptom Endpoint Note: The CAE was not used for this measurement. n=42 n=44 n=45 n=38 n=43 n=47 n=46 n=40 -4.4 -5.6 -8.1 -11.4 -15.4 -16 -18.4 P=0.006 P=0.13 -19 *P<0.001 1ANCOVA, Least Squares mean. ITT-observed population. Controlled Adverse Environment (CAE). P=0.021 2ANCOVA, Least Squares mean. ITT-observed population. *nominal p-value Placebo 0.12 mg/ml 0.6 mg/ml 1.2 mg/ml 18 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in EDS Score (mm) Mean Change in EDS Score (mm)Statistically Significant Improvement in Symptoms Mean Change from Baseline in Eye Mean Change from Baseline in Eye 1 2 Dryness Score (EDS) – Day 21 Dryness Score (EDS) – Day 28 Controlled Adverse Environment (CAE) Secondary Symptom Endpoint Secondary Symptom Endpoint Note: The CAE was not used for this measurement. n=42 n=44 n=45 n=38 n=43 n=47 n=46 n=40 -4.4 -5.6 -8.1 -11.4 -15.4 -16 -18.4 P=0.006 P=0.13 -19 *P<0.001 1ANCOVA, Least Squares mean. ITT-observed population. Controlled Adverse Environment (CAE). P=0.021 2ANCOVA, Least Squares mean. ITT-observed population. *nominal p-value Placebo 0.12 mg/ml 0.6 mg/ml 1.2 mg/ml 18 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in EDS Score (mm) Mean Change in EDS Score (mm)


Statistically Significant Benefit in Corneal Staining Mean Change in Cornea Staining Score – Day 28 Favors Favors OC-01 Placebo SD=Standard Deviation *OC-01 1.2 mg/ml was not statistically significant, but showed directional benefit favoring total, central, temporal, inferior, and nasal staining as compared to placebo (vehicle). 19 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryStatistically Significant Benefit in Corneal Staining Mean Change in Cornea Staining Score – Day 28 Favors Favors OC-01 Placebo SD=Standard Deviation *OC-01 1.2 mg/ml was not statistically significant, but showed directional benefit favoring total, central, temporal, inferior, and nasal staining as compared to placebo (vehicle). 19 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Safety and Tolerability Profile Adverse Events Potentially Related to OC-01 Administration Events in >5% of subjects OC-01 OC-01 OC-01 Placebo (0.12 mg/mL) (0.6 mg/mL) (1.2 mg/mL) Preferred Term (n=43) (n=47) (n=48) (n=44) Sneeze after any instillation 29 (62) 38 (79) 37 (84) 0 Cough after any instillation 4 (9) 6 (13) 11 (25) 0 Throat irritation after any instillation 0 7 (15) 9 (20) 0 Instillation site irritation after any instillation 3 (6) 8 (17) 8 (18) 0 Pharynx dysaesthesia after any instillation 5 (11) 4 (8) 3 (7) 0 Unique delivery in an ocular All events mild (82%) or All events transient and surface sparing nasal spray with moderate (18%) in severity. resolved by the next visit. no ocular burning/stinging, No severe events. taste or smell. 20 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietarySafety and Tolerability Profile Adverse Events Potentially Related to OC-01 Administration Events in >5% of subjects OC-01 OC-01 OC-01 Placebo (0.12 mg/mL) (0.6 mg/mL) (1.2 mg/mL) Preferred Term (n=43) (n=47) (n=48) (n=44) Sneeze after any instillation 29 (62) 38 (79) 37 (84) 0 Cough after any instillation 4 (9) 6 (13) 11 (25) 0 Throat irritation after any instillation 0 7 (15) 9 (20) 0 Instillation site irritation after any instillation 3 (6) 8 (17) 8 (18) 0 Pharynx dysaesthesia after any instillation 5 (11) 4 (8) 3 (7) 0 Unique delivery in an ocular All events mild (82%) or All events transient and surface sparing nasal spray with moderate (18%) in severity. resolved by the next visit. no ocular burning/stinging, No severe events. taste or smell. 20 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Phase 2 Study Design Single center, randomized, controlled, single-masked clinical trial to evaluate the chronic efficacy of OC-01 nasal spray on signs of dry eye disease Met primary endpoint of Mean Change in n=41 1.2 mg/ml Schirmer’s Score at Day 84 OC-01 Nasal Spray Statistically significant improvements Randomized in Schirmer’s score compared to placebo 1:1:1 n=41 0.6 mg/ml shown as early as 7 days OC-01 Schirmer’s BID for Nasal Spray Sustainable efficacy at 84 days with BID Score ≤10 mm 84 Days dosing regimen at both 0.6 mg/ml and OSDI ≥23 1.2 mg/ml Placebo n=41 (Vehicle Magnitude of tear production consistent Control) with prior studies of OC-01 at 28 Days N=123 21 ©2019 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Phase 2 Study Design Single center, randomized, controlled, single-masked clinical trial to evaluate the chronic efficacy of OC-01 nasal spray on signs of dry eye disease Met primary endpoint of Mean Change in n=41 1.2 mg/ml Schirmer’s Score at Day 84 OC-01 Nasal Spray Statistically significant improvements Randomized in Schirmer’s score compared to placebo 1:1:1 n=41 0.6 mg/ml shown as early as 7 days OC-01 Schirmer’s BID for Nasal Spray Sustainable efficacy at 84 days with BID Score ≤10 mm 84 Days dosing regimen at both 0.6 mg/ml and OSDI ≥23 1.2 mg/ml Placebo n=41 (Vehicle Magnitude of tear production consistent Control) with prior studies of OC-01 at 28 Days N=123 21 ©2019 Oyster Point Pharma, Inc.: Confidential & Proprietary


MYSTIC Subject Demographics Placebo 0.6 mg/ml 1.2 mg/ml Total (n=41) (n=41) (n=41) (n=123) Mean Age at Randomization (years) 55.8 51.4 54.2 53.8 Age Range (min, max) 26, 77 28, 74 28, 74 26, 77 Male n (%) 8 (19.5) 9 (22) 6 (14.6) 23 (18.7) Sex Female n (%) 33 (80.5) 32 (78) 35 (85.4) 100 (81.3) White n (%) 0 0 0 0 Black or African American n (%) 0 0 0 0 Race Asian n (%) 0 0 0 0 Other n (%) 41 (100) 41 (100) 41 (100) 123 (100) Not Hispanic or Latino n (%) 0 0 0 0 Ethnicity Hispanic or Latino n (%) 41 (100) 41 (100) 41 (100) 123 (100) Mean Baseline Schirmer’s Test (with anesthesia, mm) 5.3 5.5 5.4 5.4 22 ©2019 Oyster Point Pharma, Inc.: Confidential & ProprietaryMYSTIC Subject Demographics Placebo 0.6 mg/ml 1.2 mg/ml Total (n=41) (n=41) (n=41) (n=123) Mean Age at Randomization (years) 55.8 51.4 54.2 53.8 Age Range (min, max) 26, 77 28, 74 28, 74 26, 77 Male n (%) 8 (19.5) 9 (22) 6 (14.6) 23 (18.7) Sex Female n (%) 33 (80.5) 32 (78) 35 (85.4) 100 (81.3) White n (%) 0 0 0 0 Black or African American n (%) 0 0 0 0 Race Asian n (%) 0 0 0 0 Other n (%) 41 (100) 41 (100) 41 (100) 123 (100) Not Hispanic or Latino n (%) 0 0 0 0 Ethnicity Hispanic or Latino n (%) 41 (100) 41 (100) 41 (100) 123 (100) Mean Baseline Schirmer’s Test (with anesthesia, mm) 5.3 5.5 5.4 5.4 22 ©2019 Oyster Point Pharma, Inc.: Confidential & Proprietary


Study Eye- Primary Endpoint Statistically Significant Improvement In Schirmer’s Score at Day 84 Study Eye Mean Change from Baseline in Schirmer’s Score (mm) LOCF Analysis Observed Analysis p=0.01 p=0.01 P<0.05 P<0.05 12.0 12.0 11.0 11.0 10.8 10.6 10.0 10.0 8.0 8.0 6.2 6.0 6.0 6.0 4.0 4.0 2.0 2.0 0.0 0.0 Day 84 Day 84 Placebo 0.6 mg/ml 1.2 mg/ml Placebo 0.6 mg/ml 1.2 mg/ml n=32 n=35 n=29 n=41 n=41 n=41 Intent To Treat- Observed Intent To Treat-Last Observation Carried Forward * ANCOVA, Least Squares mean * ANCOVA, Least Squares mean 23 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm)Study Eye- Primary Endpoint Statistically Significant Improvement In Schirmer’s Score at Day 84 Study Eye Mean Change from Baseline in Schirmer’s Score (mm) LOCF Analysis Observed Analysis p=0.01 p=0.01 P<0.05 P<0.05 12.0 12.0 11.0 11.0 10.8 10.6 10.0 10.0 8.0 8.0 6.2 6.0 6.0 6.0 4.0 4.0 2.0 2.0 0.0 0.0 Day 84 Day 84 Placebo 0.6 mg/ml 1.2 mg/ml Placebo 0.6 mg/ml 1.2 mg/ml n=32 n=35 n=29 n=41 n=41 n=41 Intent To Treat- Observed Intent To Treat-Last Observation Carried Forward * ANCOVA, Least Squares mean * ANCOVA, Least Squares mean 23 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm)


Fellow Eye- Exploratory Statistically Significant Improvement In Schirmer’s Score at Day 84 Fellow Eye Mean Change from Baseline in Schirmer’s Score (mm) LOCF Analysis Observed Analysis p=0.01 11.0 11.0 P<0.05 P<0.05 10.0 p=0.07 8.7 8.7 9.0 9.0 7.9 7.0 7.0 4.8 4.5 5.0 5.0 3.0 3.0 1.0 1.0 Day 84 Day 84 -1.0 -1.0 Placebo 0.6 mg/ml 1.2 mg/ml Placebo 0.6 mg/ml 1.2 mg/ml n=32 n=35 n=29 n=41 n=41 n=41 Intent To Treat- Observed Intent To Treat-Last Observation Carried Forward * ANCOVA, Least Squares mean * ANCOVA, Least Squares mean 24 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm)Fellow Eye- Exploratory Statistically Significant Improvement In Schirmer’s Score at Day 84 Fellow Eye Mean Change from Baseline in Schirmer’s Score (mm) LOCF Analysis Observed Analysis p=0.01 11.0 11.0 P<0.05 P<0.05 10.0 p=0.07 8.7 8.7 9.0 9.0 7.9 7.0 7.0 4.8 4.5 5.0 5.0 3.0 3.0 1.0 1.0 Day 84 Day 84 -1.0 -1.0 Placebo 0.6 mg/ml 1.2 mg/ml Placebo 0.6 mg/ml 1.2 mg/ml n=32 n=35 n=29 n=41 n=41 n=41 Intent To Treat- Observed Intent To Treat-Last Observation Carried Forward * ANCOVA, Least Squares mean * ANCOVA, Least Squares mean 24 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm)


Study Eye Showed Early and Sustained Improvement In Schirmer’s Score to Day 84 Study Eye Mean Change from Baseline in Schirmer’s Score (mm) 13.0 12.3 11.5 Highlights: 11.0 10.7 10.6 10.5 11.0 10.4 10.3 - Early Improvement in 9.0 mean change in 7.0 6.9 Schirmer’s score for 7.0 6.3 6.3 both groups in the study eye 5.0 3.0 - Consistent tear film production with 1.0 twice daily dosing at all visits to Day 84 n=31 n=35 n=30 n=33 n=35 n=31 n=31 n=34 n=31 n=35 n=29 n=32 Day 7 Day 28 Day 56 Day 84 -1.0 Placebo 0.6 mg/ml 1.2 mg/ml Intent To Treat- Observed * Mean Change from Baseline 25 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm)Study Eye Showed Early and Sustained Improvement In Schirmer’s Score to Day 84 Study Eye Mean Change from Baseline in Schirmer’s Score (mm) 13.0 12.3 11.5 Highlights: 11.0 10.7 10.6 10.5 11.0 10.4 10.3 - Early Improvement in 9.0 mean change in 7.0 6.9 Schirmer’s score for 7.0 6.3 6.3 both groups in the study eye 5.0 3.0 - Consistent tear film production with 1.0 twice daily dosing at all visits to Day 84 n=31 n=35 n=30 n=33 n=35 n=31 n=31 n=34 n=31 n=35 n=29 n=32 Day 7 Day 28 Day 56 Day 84 -1.0 Placebo 0.6 mg/ml 1.2 mg/ml Intent To Treat- Observed * Mean Change from Baseline 25 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm)


Magnitude of Tear Production Consistent with Prior Studies of OC-01 at Day 28 11.5 12.0 12.0 11.4 11.1 10.3 10.0 10.0 8.0 8.0 6.0 6.0 4.0 4.0 2.0 2.0 0.0 0.0 Day 28 Day 28 0.6 mg/ml 1.2 mg/ml 0.6 mg/ml 1.2 mg/ml Intent To Treat- Observed * ANCOVA, Least Squares mean n=46 n=34 n=40 n=31 26 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm) Mean Change in Schirmer’s Score* (mm)Magnitude of Tear Production Consistent with Prior Studies of OC-01 at Day 28 11.5 12.0 12.0 11.4 11.1 10.3 10.0 10.0 8.0 8.0 6.0 6.0 4.0 4.0 2.0 2.0 0.0 0.0 Day 28 Day 28 0.6 mg/ml 1.2 mg/ml 0.6 mg/ml 1.2 mg/ml Intent To Treat- Observed * ANCOVA, Least Squares mean n=46 n=34 n=40 n=31 26 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary Mean Change in Schirmer’s Score* (mm) Mean Change in Schirmer’s Score* (mm)


OC-01 Safety and Tolerability Profile Adverse Events Potentially Related to OC-01 Administration Events in >1 subjects in any group OC-01 OC-01 Placebo (0.6 mg/mL) (1.2 mg/mL) (vehicle control) Adverse Event (Preferred Term) (n=41) (n=41) (n=41) n (%) n (%) n (%) Visual Acuity Reduced 4 (9.8) 1 (2.4) 0 Sneeze after any instillation 2 (4.9) 3 (7.3) 2 (4.9) Headache 2 (4.9) 2 (4.9) 0 Throat irritation after any instillation 2 (4.9) 0 0 Nosebleed 0 0 2 (4.9) Nasal Discomfort 1 (2.4) 0 1 (2.4) All events transient and All drug related events mild No Serious Adverse Events resolved by the next visit 27 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Safety and Tolerability Profile Adverse Events Potentially Related to OC-01 Administration Events in >1 subjects in any group OC-01 OC-01 Placebo (0.6 mg/mL) (1.2 mg/mL) (vehicle control) Adverse Event (Preferred Term) (n=41) (n=41) (n=41) n (%) n (%) n (%) Visual Acuity Reduced 4 (9.8) 1 (2.4) 0 Sneeze after any instillation 2 (4.9) 3 (7.3) 2 (4.9) Headache 2 (4.9) 2 (4.9) 0 Throat irritation after any instillation 2 (4.9) 0 0 Nosebleed 0 0 2 (4.9) Nasal Discomfort 1 (2.4) 0 1 (2.4) All events transient and All drug related events mild No Serious Adverse Events resolved by the next visit 27 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Next: Pivotal Phase 3 Data; Topline Data On Track for Mid-2020 Multicenter, Randomized, Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy and Safety of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease Primary (sign) Endpoint: n=250 1.2 mg/ml • Schirmer’s Score at day 28 OC-01 Nasal Spray Secondary (symptom) Endpoints: Randomized • Visual analog eye dryness score (EDS) 1:1:1 n=250 0.6 mg/ml in CAE at day 28 OC-01 Schirmer’s BID for Nasal Spray • Visual analog eye dryness score (EDS) Score ≤10 mm 28 Days in at day 28 OSDI ≥23 Placebo • Additional Schirmer’s measurements n=250 (Vehicle Control) • Fluorescein corneal staining 28 ©2019 Oyster Point Pharma, Inc.: Confidential & ProprietaryNext: Pivotal Phase 3 Data; Topline Data On Track for Mid-2020 Multicenter, Randomized, Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy and Safety of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease Primary (sign) Endpoint: n=250 1.2 mg/ml • Schirmer’s Score at day 28 OC-01 Nasal Spray Secondary (symptom) Endpoints: Randomized • Visual analog eye dryness score (EDS) 1:1:1 n=250 0.6 mg/ml in CAE at day 28 OC-01 Schirmer’s BID for Nasal Spray • Visual analog eye dryness score (EDS) Score ≤10 mm 28 Days in at day 28 OSDI ≥23 Placebo • Additional Schirmer’s measurements n=250 (Vehicle Control) • Fluorescein corneal staining 28 ©2019 Oyster Point Pharma, Inc.: Confidential & Proprietary


Neurotrophic Keratitis (NK) NK is rare, degenerative disease resulting from a loss of corneal sensation, Disease which causes progressive damage to the cornea Causes Herpes simplex, varicella zoster (shingles), diabetes, multiple sclerosis, leprosy Corneal hypoesthesia/anesthesia, decreased tearing and blinking. Pathophysiology Decreased corneal lubrication and epithelial healing Artificial tears, surgery, topical nerve growth factor (NGF) Treatment 1 NK is a rare disease with an estimated prevalence of less than 5/10,000 Market Size Treatment with NGF is cumbersome to administer-6 times per day for eight Unmet need weeks at a cost of >$90K per treatment course 1 National Organization for Rare Disease (NORD) Accessed from https://rarediseases.org/rare-diseases/neurotrophic-keratitis/ 29 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryNeurotrophic Keratitis (NK) NK is rare, degenerative disease resulting from a loss of corneal sensation, Disease which causes progressive damage to the cornea Causes Herpes simplex, varicella zoster (shingles), diabetes, multiple sclerosis, leprosy Corneal hypoesthesia/anesthesia, decreased tearing and blinking. Pathophysiology Decreased corneal lubrication and epithelial healing Artificial tears, surgery, topical nerve growth factor (NGF) Treatment 1 NK is a rare disease with an estimated prevalence of less than 5/10,000 Market Size Treatment with NGF is cumbersome to administer-6 times per day for eight Unmet need weeks at a cost of >$90K per treatment course 1 National Organization for Rare Disease (NORD) Accessed from https://rarediseases.org/rare-diseases/neurotrophic-keratitis/ 29 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Phase 2b Neurotrophic Keratitis Multicenter, Randomized, Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray in Subjects with Neurotrophic Keratitis Primary Endpoint: n=50 Percent of subjects who achieve complete 1.2 mg/ml OC-01 resolution of corneal staining (defined as Nasal Spray complete resolution of corneal staining (0 mm lesion and no residual staining) in Randomized 1:1:1 subjects with Stage 2 (Persistent Epithelial n=50 0.6 mg/ml Defect [PED]) and Stage 3 (corneal ulcer) OC-01 BID for Nasal Spray neurotrophic keratitis 56 Days Secondary Endpoints: Placebo • Duration of corneal healing (<0.5 mm n=50 (Vehicle lesion size) Control) • Improvement in corneal sensitivity 30 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryPhase 2b Neurotrophic Keratitis Multicenter, Randomized, Controlled, Double-Masked Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray in Subjects with Neurotrophic Keratitis Primary Endpoint: n=50 Percent of subjects who achieve complete 1.2 mg/ml OC-01 resolution of corneal staining (defined as Nasal Spray complete resolution of corneal staining (0 mm lesion and no residual staining) in Randomized 1:1:1 subjects with Stage 2 (Persistent Epithelial n=50 0.6 mg/ml Defect [PED]) and Stage 3 (corneal ulcer) OC-01 BID for Nasal Spray neurotrophic keratitis 56 Days Secondary Endpoints: Placebo • Duration of corneal healing (<0.5 mm n=50 (Vehicle lesion size) Control) • Improvement in corneal sensitivity 30 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Commercialization of OC-01 Planning 1st Launch in the US in Q4 2021 Key commercialization strategies include: Focused direct-to- Specialty sales force of Selective contracting for consumer campaigns to 150 to 200 representatives broad payer coverage targeting high volume people diagnosed with and retail pharmacy DED leveraging novel Ophthalmologists and distribution Optometrists MOA & Nasal Spray Sales force could also support We will consider potential the commercialization of partnerships for international additional ocular therapies commercialization 31 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryCommercialization of OC-01 Planning 1st Launch in the US in Q4 2021 Key commercialization strategies include: Focused direct-to- Specialty sales force of Selective contracting for consumer campaigns to 150 to 200 representatives broad payer coverage targeting high volume people diagnosed with and retail pharmacy DED leveraging novel Ophthalmologists and distribution Optometrists MOA & Nasal Spray Sales force could also support We will consider potential the commercialization of partnerships for international additional ocular therapies commercialization 31 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


Strong Global IP Position OC-01 (Varenicline) Nasal Spray OC-01, commercialized compound with patent exclusivity as a nasal spray in ocular surface disease § US license granted for varenicline tartrate by Pfizer § Three US method patents issued: expire 2035 § US formulation patent issued: expires 2035 § US method application pending Global filing initiated § Australia, Brazil, Canada, China, Eurasia (includes Russia), Europe, Hong Kong (via EP), Israel, Japan, Korea, Malaysia, Mexico, Philippines, Singapore, South Africa § Ex-US expiration as early as 2035 32 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryStrong Global IP Position OC-01 (Varenicline) Nasal Spray OC-01, commercialized compound with patent exclusivity as a nasal spray in ocular surface disease § US license granted for varenicline tartrate by Pfizer § Three US method patents issued: expire 2035 § US formulation patent issued: expires 2035 § US method application pending Global filing initiated § Australia, Brazil, Canada, China, Eurasia (includes Russia), Europe, Hong Kong (via EP), Israel, Japan, Korea, Malaysia, Mexico, Philippines, Singapore, South Africa § Ex-US expiration as early as 2035 32 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


OC-01 Nasal Spray Expected Timeline to Approval NDA Submission - 2H 2020 New Drug Application NDA Approval - 2H 2021 Enrollment Complete- Q3 2018 Enrollment Complete - Q3 2019 Topline Data- Q4 2018 Topline Data - Q4 2019 Enrollment Complete - Q3 2019 Enrollment Complete- 1H 2020 Topline Data (Day 84) - Q1 2020 Topline Data (Day 28)- MID 2020 33 ©2020 Oyster Point Pharma, Inc.: Confidential & ProprietaryOC-01 Nasal Spray Expected Timeline to Approval NDA Submission - 2H 2020 New Drug Application NDA Approval - 2H 2021 Enrollment Complete- Q3 2018 Enrollment Complete - Q3 2019 Topline Data- Q4 2018 Topline Data - Q4 2019 Enrollment Complete - Q3 2019 Enrollment Complete- 1H 2020 Topline Data (Day 84) - Q1 2020 Topline Data (Day 28)- MID 2020 33 ©2020 Oyster Point Pharma, Inc.: Confidential & Proprietary


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